ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might have originated from the recombination of a Pangolin-CoV-like virus with a Bat-CoV-RaTG13-like virus and then transmitted to a human at Wuhan city of China. On February 11, 2020, the WHO announced a name for the new coronavirus disease as COVID-19. Finally, the WHO declared the novel coron-avirus outbreak a global pandemic on March 11, 2020. Within a few months, SARS-CoV-2 had spread across the world to 220 countries, areas or territories. The main objective of this work is to review the existing knowledge about COVID-19, its updated status, available treatment procedures and future challenges. The available literature based on the COVID-19 was thoroughly reviewed and concise, evidence-based information was explored for the public interest. Various authentic databases like PubMed, Scopus, and Google Scholar together with the official sites of some Govt. Organizations were carefully searched for all relevant information about the current status of COVID-19, including the published research on coronavirus. More than 68 million people are already infected, including around 20% severely ill, with almost 1.5 million casualties due to this virus which is expected to infect approximately 70% population worldwide. Currently, maximum confirmed cases and death are reported in the USA. The epicentre of the pandemic was initially shifted from China to Europe, then to the USA, Brazil and now India. In between, the understanding of pathogenesis and mode of transmission has been developed;repurposing drugs are being validated and the development of a new vaccine is underway. The study concludes that there is no established treatment available for COVID-19, although 26 clinical and 139 preclinical trials are un-derway to develop vaccines globally. Although three vaccines are at the advanced stage of develop-ment, their efficacy and adverse effects are yet to be validated and recorded. Recently, the Pfizer vaccine has been started for vaccination in emergency cases in England and Bahrain, and the United States of America will start it soon. Meanwhile, prevention, rigorous global containment and quarantine efforts are practiced worldwide to control its spread.Copyright © 2021 Bentham Science Publishers.
ABSTRACT
The purpose of this analysis is to double-check the phrasing in order to make it simpler for experts and scientists to comprehend the impact of the coronavirus on the tourism industry and develop solutions to this problem. This study looks at how and why the pandemic has affected people's freedoms by analyzing the events and worries that have arisen as a result of the virus's spread. By doing so, the study pinpoints personality traits, societal norms, and unproven assumptions that the tourist sector needs to challenge and change. The report also examines the severe difficulties encountered by the travel industry throughout the Coronavirus phases and analyses some issues with the proposed remedy based on Salesforce technology. This document summarizes the nature and scope of the coronavirus, its effects on the tourism sector, and suggestions for analyzing those effects and mitigating some of them through the use of Salesforce's 'Travel Log Analysis.' © 2022 IEEE.
ABSTRACT
Background The frequent lockdown in Nepal during COVID-19 pandemic had brought various kinds of complexities such as stress among college students. This situation had created uncertainty of future academic career of undergraduate students in medical colleges. Some previously published literature showed gaming as a coping mechanism against stress. Objective To assess the gaming behavior of Medical college students during lockdown in COVID-19 pandemic. Method A cross-sectional study was conducted during lockdown period of July to August 2020. A total of 412 college students were enrolled. Online Google forms were shared to all the eligible students through email, viber and messenger with the help of class representative. Collected data were analyzed in SPSS version 20.0. Result The prevalence of gaming disorder was 8.5% among 260 internet gaming users. About 69.2% of the participants reported that their gaming behavior had increased due to stress of COVID-19 pandemic. Gender and spending more time online per day showed significant associations with greater scores on the internet gaming disorder. Conclusion During lockdown period of COVID-19 pandemic, the gaming behavior of medical college students has increased. Copyright © 2020, Kathmandu University. All rights reserved.
ABSTRACT
Health systems and their trends are continually evolving with advanced research on new tools and techniques. Since every health system has its limitations, there is a requirement for the integration of different medical systems to better serve mankind. In this direction, a practitioner of modern medicine should take into consideration traditional medicine practices, while the traditional medicine practitioner should also integrate the beneficial strategies of modern medicine. In spite of different approaches, the aim of all these medical systems is the same, which is to serve mankind by treating various health problems. Although traditional medicine has the potential to treat a variety of diseases, its acceptance by the global community is less than that of modern medicine due to inadequate scientific validation of its therapeutic benefits. In recent years, many new diseases have emerged, perhaps due to changes in geography, environment, weather conditions, and soil composition. A complete treatment of such diseases is a challenge for all medical practitioners, whether belonging to modern or traditional medicine. Therefore, an in-depth multidisciplinary research is needed to find an effective therapeutic strategy by connecting modern and traditional medical systems with biomedical sciences. In this direction, biotechnology can play an important role in developing a diagnostic method and treatment protocol. The present review provides an overview of the available Ayurvedic treatment options and future possibilities in which biotechnology may assist as a service provider. Copyright © 2023 Bentham Science Publishers.
ABSTRACT
One of the best measures to enforce in epidemiological scenarios, such as the present COVID-19 epidemic, is the usage of masks. For a while, this will be a regular part of life, notably in public places. In order to deal with these unusual circumstances where people who wear mask are being watched, there is a need for an effective face identification technology. In order to precisely identify people wearing masks, we provide a deep learning algorithm based on YOLO architecture in this study. Unlike traditional CNNs, the proposed system uses a convergence layer to record numerous facial emotions while also using a number of convolutional filters to construct the faces for masked images. The presented design has numerous layers, including convolutional, max pooling, dropout, and softmax, and is both straightforward and effective. On the publicly accessible Real-World Masked Face Dataset, we assess the effectiveness of masked-faces detection (RWMFD). The investigational outcomes demonstrate an accurateness of 99.9%, demonstrating the effectiveness of our proposed methodology in classifying individuals wanting to wear facemasks. © 2022 IEEE.
ABSTRACT
Ayurveda and Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan from the Ayurvedic system are the two major formulations along with many other individual herbs mentioned in the texts to treat Influenza like infections. Kabasura churan and Maha Sudarshan churan both have antipyretic, analgesic and anti-inflammatory effects. Both formulations were prepared according to Siddha and Ayurvedic texts. Herbs mentioned in both formulations like Turmeric, Tulsi (Basil), Kalmegh (Andrographis), Black Pepper, Liquorice (Mulethi), and Dronapushpi (Leucas) etc., had direct antiviral effect. Herbs like Aswagandha, Ginger, Guduchi (Tinospora), Kulanjan (Galangal) etc., had immunomodulatory and anti-inflammatory effect. Active compounds from different herbs were selected to study their antiviral activity through molecular docking algorithm. Application of modern of tools like Bioinformatics and Highthroughput screening methods can predict the efficacy of the ancient documented formulations and can be compared as per their literature. Compounds like curcumin, Glycyrrhizin, Ursolic acid, Quercetin, Andrographolide, Coumarins etc. were showed polyspecific activity like inhibition of Spike protein, Furin, Main Protease (Mpro) and Papain like Proteases (PLpro). Thus we propose use of Kabasura churan and Maha Sudharshan churan as alternative complementary medicine as a palliative treatment against COVID-19 caused by SARS-CoV-2 by conducting proper Randomized Clinical Trials.
ABSTRACT
Background The frequent lockdown in Nepal during COVID-19 pandemic had brought various kinds of complexities such as stress among college students. This situation had created uncertainty of future academic career of undergraduate students in medical colleges. Some previously published literature showed gaming as a coping mechanism against stress. Objective To assess the gaming behavior of Medical college students during lockdown in COVID-19 pandemic. Method A cross-sectional study was conducted during lockdown period of July to August 2020. A total of 412 college students were enrolled. Online Google forms were shared to all the eligible students through email, viber and messenger with the help of class representative. Collected data were analyzed in SPSS version 20.0. Result The prevalence of gaming disorder was 8.5% among 260 internet gaming users. About 69.2% of the participants reported that their gaming behavior had increased due to stress of COVID-19 pandemic. Gender and spending more time online per day showed significant associations with greater scores on the internet gaming disorder. Conclusion During lockdown period of COVID-19 pandemic, the gaming behavior of medical college students has increased.